Protein Details: KCa3.1 (Potassium intermediate/small conductance calcium-activated channel; subfamily N; member 4)
Protein ID
ICDB_Pro_1608
Protein Name
KCa3.1 (Potassium intermediate/small conductance calcium-activated channel; subfamily N; member 4)
Gene Name
Kcnn4; Ik1; Sk4; Smik
Organism
Rattus norvegicus (Rat)
Length
425 amino acids
AlphaFoldDB
AF-Q9QYW1-F1-model_v4.pdb
Function
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin
Sequence
MGGELVTGLGALRRRKRLLEQEKRVAGWALVLAGTGIGLMVLHAEMLWFLGCKWVLYLLLVKCLITLSTAFLLCLIVVFHAKEVQLFMTDNGLRDWRVALTRRQVAQILLELLVCGVHPVPLRSPHCTLAGEATDSQAWPGFLGEGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLTDTLWLIPITFLTIGYGDVVPGTLWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIHYAKEMKESAARLLQEAWMYYKHTRRKDSRAARRHQRKMLAAIHTFRQVRLKHRKLREQVNSMVDISKMHMILCDLQLGLSASHLALEKRIDGLAGKLDALTELLSTALQQQQPPEPIQEAT
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1161/01.res.85.9.e33; 10.1007/s004249900059